Profhilo

High-Concentration Hyaluronic Acid Bioremodelling — Restoring Skin Quality and Firmness

Profhilo® is an injectable skin-remodelling treatment containing one of the highest concentrations of pure, stabilised hyaluronic acid available in aesthetic medicine — 64 mg per 2 ml syringe. Formulated through patented NAHYCO® Hybrid Technology, it produces a uniquely biocompatible, thermally stabilised HA without chemical cross-linking agents — an important distinction from both conventional fillers and other skin boosters.

This distinctive molecular architecture allows Profhilo® to flow freely beneath the skin following injection, distributing broadly across tissue and exerting bioremodelling effects across multiple cell types. It addresses skin laxity, dehydration, and quality deterioration at a biological level — not by filling or volumising, but by stimulating the skin's own regenerative processes.

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Who is Profhilo® For?

Profhilo® is suitable for individuals experiencing:

• Skin laxity — loss of firmness and structural support
• Fine lines and early-to-moderate wrinkles
• Dehydrated skin with impaired moisture retention
• Dull, tired-looking skin lacking luminosity
• Early signs of intrinsic ageing — reduced collagen and elastin quality

Treatment areas extend beyond the face to include the neck, décolletage, hands, and arms. A medical consultation is required to assess suitability and define individualised goals.

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The Science: Bioremodelling Explained

Hydration at the Cellular Level

Hyaluronic acid is hygroscopic — capable of binding water molecules up to 1,000 times its own weight. Profhilo® dramatically increases dermal hydration, restoring the skin's moisture reservoir and improving turgor and suppleness from within.

Collagen and Elastin Stimulation

The high-concentration HA stimulates multiple cell types involved in extracellular matrix production. Fibroblasts are activated to produce new Type I and Type III collagen and elastin; keratinocytes and adipocytes respond to the bioactive HA environment. This multi-cell stimulation drives progressive structural improvement — translating clinically into firmer, smoother, more resilient skin over time.

The BAP Technique

Profhilo® is administered via the Bio Aesthetic Points (BAP) protocol — five standardised injection points per side of the face — optimised to maximise tissue distribution from minimal injection sites, reducing discomfort and procedural risk.

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What to Expect

1. Session length: 20 to 30 minutes including preparation.
2. Protocol: Two sessions, 4 weeks apart — standard primary course.
3. Downtime: Minimal. Small papules 24 to 48 hours; occasional bruising.
4. First results: Initial improvement within 2 to 4 weeks.
5. Full results: Optimal after the second session as collagen builds.
6. Duration: 6 to 12 months; individual variation applies.
7. Maintenance: Every 6 to 12 months depending on skin ageing and goals.

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Risks, Preparation, and Aftercare

Profhilo® is generally well tolerated. Common temporary effects include mild swelling, redness, tenderness, bruising, and small injection-site papules. Less commonly, infection, allergic reactions, or prolonged swelling may occur. Vascular complications, though rare, represent a serious risk with any injectable treatment and underscore the importance of treatment by an appropriately qualified healthcare professional.

Before treatment:

• Disclose all medications and supplements, particularly those affecting coagulation
• Avoid alcohol for 24 hours

After treatment:

• Avoid touching or massaging treated areas
• Refrain from strenuous exercise and heat exposure for 24 to 48 hours
• Maintain consistent daily SPF 50+ protection throughout the treatment course